Assay Detail
Functional
CHEMBL618060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.74 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355423 | — | — | 1 | 6.70 |
| CHEMBL168339 | — | — | 1 | 6.40 |
| CHEMBL445386 | — | — | 1 | 6.40 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.30 |
| CHEMBL167577 | — | — | 1 | 6.22 |
| CHEMBL166844 | — | — | 1 | 5.54 |
| CHEMBL166644 | — | — | 1 | 5.32 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.92 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 4.85 |
| CHEMBL154 | NAPROXEN | 4.0 | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355423 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL168339 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL445386 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL93 | ZILEUTON | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL167577 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL166844 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL166644 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL154 | NAPROXEN | IC50 | = | 17000.0 | nM | 4.77 |