Assay Detail
Binding
CHEMBL618063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formation
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 63 | 5.01 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127109 | — | — | 1 | 5.96 |
| CHEMBL340896 | — | — | 1 | 5.82 |
| CHEMBL7660 | PHENIDONE | — | 1 | 5.72 |
| CHEMBL129344 | — | — | 1 | 5.68 |
| CHEMBL129260 | — | — | 1 | 5.62 |
| CHEMBL129506 | — | — | 1 | 5.58 |
| CHEMBL126672 | — | — | 1 | 5.57 |
| CHEMBL126135 | — | — | 1 | 5.55 |
| CHEMBL340784 | — | — | 1 | 5.46 |
| CHEMBL129798 | — | — | 1 | 5.46 |
| CHEMBL127110 | — | — | 1 | 5.42 |
| CHEMBL339537 | — | — | 1 | 5.41 |
| CHEMBL30110 | — | — | 1 | 5.37 |
| CHEMBL128657 | — | — | 1 | 5.32 |
| CHEMBL339239 | — | — | 1 | 5.31 |
| CHEMBL128664 | — | — | 1 | 5.31 |
| CHEMBL126290 | — | — | 1 | 5.28 |
| CHEMBL129441 | — | — | 1 | 5.26 |
| CHEMBL338785 | — | — | 1 | 5.26 |
| CHEMBL126183 | — | — | 1 | 5.25 |
| CHEMBL126191 | — | — | 1 | 5.22 |
| CHEMBL126949 | — | — | 1 | 5.22 |
| CHEMBL341363 | — | — | 1 | 5.20 |
| CHEMBL129428 | — | — | 1 | 5.18 |
| CHEMBL340927 | — | — | 1 | 5.17 |
| CHEMBL129531 | — | — | 1 | 5.17 |
| CHEMBL128308 | — | — | 1 | 5.16 |
| CHEMBL129325 | — | — | 1 | 5.09 |
| CHEMBL128758 | — | — | 1 | 5.08 |
| CHEMBL341057 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127109 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL340896 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL129344 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL129260 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL129506 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL126672 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL126135 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL340784 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL129798 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL127110 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL339537 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL30110 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL128657 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL128664 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL339239 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL126290 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL129441 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL338785 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL126183 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL126191 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL126949 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL341363 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL129428 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL129531 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL340927 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL128308 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL129325 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL128758 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL341057 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL128429 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL128138 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL129799 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL129818 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL338350 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL129670 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL127719 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL128869 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL128663 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL341253 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL126910 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL126950 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL340341 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL129154 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL127107 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL126460 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL129369 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL6415 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL340385 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL128236 | — | IC50 | = | 32000.0 | nM | 4.50 |