Assay Detail
Binding
CHEMBL618064
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Inhibition of 5-lipoxygenase from rat peritoneal neutrophils after oral administration
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.37 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287336 | — | — | 1 | 5.96 |
| CHEMBL285278 | — | — | 1 | 5.70 |
| CHEMBL1907766 | — | — | 1 | 5.70 |
| CHEMBL36075 | — | — | 1 | 5.52 |
| CHEMBL33824 | — | — | 1 | 5.52 |
| CHEMBL1907769 | — | — | 1 | 4.75 |
| CHEMBL286635 | — | — | 1 | 4.46 |
| CHEMBL527 | PIROXICAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287336 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL285278 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1907766 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL36075 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL33824 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1907769 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL286635 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL527 | PIROXICAM | IC50 | > | 100000.0 | nM | - |