Assay Detail
Binding
CHEMBL618065
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Inhibition of 5-lipoxygenase of rat basophilic leukemia (RBL) cell cytosolic enzymes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | RBL-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
A novel series of highly potent 5-lipoxygenase inhibitors; 2-aryldienylbenzoxazoles
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.60 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413111 | — | — | 1 | 7.70 |
| CHEMBL125041 | — | — | 1 | 7.52 |
| CHEMBL332082 | — | — | 1 | 6.89 |
| CHEMBL124994 | — | — | 1 | 6.82 |
| CHEMBL125374 | — | — | 1 | 6.77 |
| CHEMBL339596 | — | — | 1 | 6.60 |
| CHEMBL125780 | — | — | 1 | 6.58 |
| CHEMBL340121 | — | — | 1 | 6.54 |
| CHEMBL125151 | — | — | 1 | 6.52 |
| CHEMBL125074 | — | — | 1 | 6.48 |
| CHEMBL125197 | — | — | 1 | 6.43 |
| CHEMBL124538 | — | — | 1 | 6.42 |
| CHEMBL17347 | ETHYL CAFFEATE | — | 1 | 5.94 |
| CHEMBL125727 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413111 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL125041 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL332082 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL124994 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL125374 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL339596 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL125780 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL340121 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL125151 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL125074 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL125197 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL124538 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL17347 | ETHYL CAFFEATE | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL125727 | — | IC50 | = | 5800.0 | nM | 5.24 |