Assay Detail
Binding
CHEMBL618067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.63 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316040 | TEPOXALIN | 2.0 | 1 | 6.82 |
| CHEMBL368145 | — | — | 1 | 6.05 |
| CHEMBL173009 | — | — | 1 | 5.75 |
| CHEMBL368546 | — | — | 1 | 5.33 |
| CHEMBL178896 | — | — | 1 | 5.29 |
| CHEMBL435907 | — | — | 1 | 5.09 |
| CHEMBL174501 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316040 | TEPOXALIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL368145 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL173009 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL368546 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL178896 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL435907 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL174501 | — | IC50 | = | 8700.0 | nM | 5.06 |