Assay Detail
Binding
CHEMBL618068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 5-lipoxygenase (5-LO) using broken rat barophilic leukemia cells (RBL-1)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.61 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368546 | — | — | 1 | 7.16 |
| CHEMBL368145 | — | — | 1 | 7.10 |
| CHEMBL435907 | — | — | 1 | 6.96 |
| CHEMBL173009 | — | — | 1 | 6.04 |
| CHEMBL316040 | TEPOXALIN | 2.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368546 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL368145 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL435907 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL173009 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL316040 | TEPOXALIN | IC50 | = | 1700.0 | nM | 5.77 |