Assay Detail
Binding
CHEMBL618091
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Binding affinity towards 5-hydroxytryptamine 6 receptor using [3H]- LSD as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.97 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355905 | — | — | 1 | 8.40 |
| CHEMBL433461 | — | — | 1 | 7.58 |
| CHEMBL145304 | — | — | 1 | 7.16 |
| CHEMBL141549 | — | — | 1 | 7.15 |
| CHEMBL358948 | — | — | 1 | 7.10 |
| CHEMBL356781 | — | — | 1 | 7.06 |
| CHEMBL144265 | — | — | 1 | 6.57 |
| CHEMBL142783 | — | — | 1 | 6.28 |
| CHEMBL356540 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355905 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL433461 | — | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL145304 | — | IC50 | = | 68.9 | nM | 7.16 |
| CHEMBL141549 | — | IC50 | = | 70.1 | nM | 7.15 |
| CHEMBL358948 | — | IC50 | = | 79.2 | nM | 7.10 |
| CHEMBL356781 | — | IC50 | = | 87.6 | nM | 7.06 |
| CHEMBL144265 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL142783 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL356540 | — | IC50 | = | 3580.0 | nM | 5.45 |