Compound Detail
CHEMBL141549
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Basic Information
| ChEMBL ID | CHEMBL141549 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BOCANXVJTHCSDS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
359.5
MW (Da)
2.93
ALogP
6
HBA
1
HBD
75.3
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | IC50 | 7.15 | 7.125 | 70.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | IC50 | = | 70.1 | nM | 7.15 | Binding affinity towards 5-hydroxytryptamine 6 receptor using [3H]- LSD as radio... | 14584934 |
| 5-hydroxytryptamine receptor 6 | IC50 | = | 80.0 | nM | 7.1 | Displacement of [3H]LSD from human cloned 5-HT6 receptor expressed in HeLa cells | 24495863 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24495863 | 10.1016/j.bmc.2014.01.003 | 5-hydroxytryptamine receptor 6 | 2 |
| 14584934 | 10.1021/jm034142q | 5-hydroxytryptamine receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine