Assay Detail
Functional
CHEMBL618156
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Antitumor activity of compound for 96-h exposure in A2780cisR (acquired resistance to cisplatin) human ovarian cell line
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780cisR |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.71 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34618 | — | — | 1 | 6.94 |
| CHEMBL34682 | — | — | 1 | 5.57 |
| CHEMBL33853 | — | — | 1 | 5.29 |
| CHEMBL301735 | HOECHST 33258 | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34618 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL34682 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL33853 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL301735 | HOECHST 33258 | IC50 | = | 9500.0 | nM | 5.02 |