Assay Detail
ADMET
CHEMBL618314
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Concentration required for 50% toxicity in metastatic lung carcinoma (MV522) cells.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Preparation and biological activity of amino acid and peptide conjugates of antitumor hydroxymethylacylfulvene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.62 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | 3.0 | 1 | 8.40 |
| CHEMBL331558 | — | — | 1 | 7.14 |
| CHEMBL121987 | ACYLFULVENE | — | 1 | 6.46 |
| CHEMBL323826 | — | — | 1 | 5.92 |
| CHEMBL326791 | — | — | 1 | 5.60 |
| CHEMBL325724 | — | — | 1 | 5.34 |
| CHEMBL325002 | — | — | 1 | 4.81 |
| CHEMBL3142961 | — | — | 1 | 4.61 |
| CHEMBL3142958 | — | — | 1 | 4.55 |
| CHEMBL118697 | — | — | 1 | 4.54 |
| CHEMBL3142959 | — | — | 1 | 4.43 |
| CHEMBL3142957 | — | — | 1 | - |
| CHEMBL118510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL331558 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL121987 | ACYLFULVENE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL323826 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL326791 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL325724 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL325002 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL3142961 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL3142958 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL118697 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL3142959 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL3142957 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL118510 | — | IC50 | > | 50000.0 | nM | - |