Assay Detail
Binding
CHEMBL618395
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.51 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152346 | — | — | 1 | 4.51 |
| CHEMBL69795 | — | — | 1 | - |
| CHEMBL173711 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152346 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL69795 | — | IC50 | = | 1.6 | — | - |
| CHEMBL173711 | — | IC50 | = | 1.5 | — | - |