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Assay Detail

CHEMBL618396

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Binding
In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)
ChEMBL ↗
108
Total Activities
107
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type RBL-1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.
Summers JB, Kim KH, Mazdiyasni H, Holms JH, Ratajczyk JD, Stewart AO, Dyer RD, Carter GW.
J Med Chem (1990) 33 : 992 -998
PubMed 2308149 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 108 5.82 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL65655 — — 1 7.66
CHEMBL154575 — — 1 7.28
CHEMBL65654 — — 1 7.19
CHEMBL177549 — — 1 7.16
CHEMBL155033 — — 1 7.09
CHEMBL63882 — — 1 7.00
CHEMBL446362 — — 1 7.00
CHEMBL174898 — — 1 7.00
CHEMBL154843 — — 1 7.00
CHEMBL368764 — — 1 6.96
CHEMBL155611 — — 1 6.92
CHEMBL367247 — — 1 6.92
CHEMBL174557 — — 1 6.89
CHEMBL177476 — — 1 6.89
CHEMBL178053 — — 1 6.89
CHEMBL367188 — — 1 6.80
CHEMBL156887 — — 1 6.75
CHEMBL175134 — — 1 6.68
CHEMBL69110 — — 1 6.55
CHEMBL366714 — — 1 6.55
CHEMBL304443 — — 1 6.54
CHEMBL65430 — — 1 6.54
CHEMBL368826 — — 1 6.52
CHEMBL174896 — — 1 6.51
CHEMBL154008 — — 1 6.48
CHEMBL176289 — — 1 6.47
CHEMBL174051 — — 1 6.44
CHEMBL68235 — — 1 6.42
CHEMBL367401 — — 1 6.42
CHEMBL307568 — — 1 6.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL65655 — IC50 = 22.0 nM 7.66
CHEMBL154575 — IC50 = 52.0 nM 7.28
CHEMBL65654 — IC50 = 64.0 nM 7.19
CHEMBL177549 — IC50 = 70.0 nM 7.16
CHEMBL155033 — IC50 = 82.0 nM 7.09
CHEMBL63882 — IC50 = 100.0 nM 7.00
CHEMBL154843 — IC50 = 100.0 nM 7.00
CHEMBL446362 — IC50 = 100.0 nM 7.00
CHEMBL174898 — IC50 = 100.0 nM 7.00
CHEMBL368764 — IC50 = 110.0 nM 6.96
CHEMBL367247 — IC50 = 120.0 nM 6.92
CHEMBL155611 — IC50 = 120.0 nM 6.92
CHEMBL178053 — IC50 = 130.0 nM 6.89
CHEMBL177476 — IC50 = 130.0 nM 6.89
CHEMBL174557 — IC50 = 130.0 nM 6.89
CHEMBL367188 — IC50 = 160.0 nM 6.80
CHEMBL156887 — IC50 = 180.0 nM 6.75
CHEMBL175134 — IC50 = 210.0 nM 6.68
CHEMBL69110 — IC50 = 280.0 nM 6.55
CHEMBL366714 — IC50 = 280.0 nM 6.55
CHEMBL65430 — IC50 = 290.0 nM 6.54
CHEMBL304443 — IC50 = 290.0 nM 6.54
CHEMBL368826 — IC50 = 300.0 nM 6.52
CHEMBL174896 — IC50 = 310.0 nM 6.51
CHEMBL154008 — IC50 = 330.0 nM 6.48
CHEMBL176289 — IC50 = 340.0 nM 6.47
CHEMBL174051 — IC50 = 360.0 nM 6.44
CHEMBL367401 — IC50 = 380.0 nM 6.42
CHEMBL68235 — IC50 = 380.0 nM 6.42
CHEMBL307568 — IC50 = 390.0 nM 6.41
CHEMBL177702 — IC50 = 410.0 nM 6.39
CHEMBL67411 — IC50 = 410.0 nM 6.39
CHEMBL66852 — IC50 = 430.0 nM 6.37
CHEMBL367924 — IC50 = 430.0 nM 6.37
CHEMBL67940 — IC50 = 450.0 nM 6.35
CHEMBL351338 — IC50 = 470.0 nM 6.33
CHEMBL177392 — IC50 = 490.0 nM 6.31
CHEMBL351785 — IC50 = 510.0 nM 6.29
CHEMBL369017 — IC50 = 560.0 nM 6.25
CHEMBL146477 — IC50 = 590.0 nM 6.23
CHEMBL367293 — IC50 = 640.0 nM 6.19
CHEMBL177499 — IC50 = 670.0 nM 6.17
CHEMBL368604 — IC50 = 720.0 nM 6.14
CHEMBL303900 — IC50 = 760.0 nM 6.12
CHEMBL177989 — IC50 = 780.0 nM 6.11
CHEMBL303033 — IC50 = 770.0 nM 6.11
CHEMBL366840 — IC50 = 830.0 nM 6.08
CHEMBL367913 — IC50 = 850.0 nM 6.07
CHEMBL178065 — IC50 = 890.0 nM 6.05
CHEMBL155443 — IC50 = 950.0 nM 6.02