Assay Detail
Binding
CHEMBL618442
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Inhibition constant against 6-phosphogluconate dehydrogenase of Trypanosoma brucei expressed in Escherichia coli
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
6-phosphogluconate dehydrogenase, decarboxylating (CHEMBL3404) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.31 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116018 | — | — | 1 | 8.00 |
| CHEMBL324609 | — | — | 1 | 7.46 |
| CHEMBL114269 | — | — | 1 | 7.10 |
| CHEMBL1160945 | — | — | 1 | 6.89 |
| CHEMBL323922 | — | — | 1 | 5.82 |
| CHEMBL1160944 | — | — | 1 | 5.46 |
| CHEMBL1160943 | — | — | 1 | 5.36 |
| CHEMBL116916 | — | — | 1 | 4.40 |
| CHEMBL114894 | — | — | 1 | - |
| CHEMBL113666 | — | — | 1 | - |
| CHEMBL117133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116018 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL324609 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL114269 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL1160945 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL323922 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL1160944 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL1160943 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL116916 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL114894 | — | Ki | = | 588000.0 | nM | - |
| CHEMBL113666 | — | Ki | = | 109000.0 | nM | - |
| CHEMBL117133 | — | Ki | = | 198000.0 | nM | - |