Assay Detail
Functional
CHEMBL618557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for cytotoxic activity against A2780cisR cell line(human ovarian carcinoma )
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | A2780cisR |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N4-(omega-Aminoalkyl)-1-[(omega-aminoalkyl)amino]-4- acridinecarboxamides: novel, potent, cytotoxic, and DNA-binding agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.27 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146276 | — | — | 1 | 7.04 |
| CHEMBL145082 | — | — | 1 | 6.92 |
| CHEMBL145428 | — | — | 1 | 6.72 |
| CHEMBL535811 | — | — | 1 | 6.44 |
| CHEMBL9940 | — | — | 1 | 6.24 |
| CHEMBL145573 | — | — | 1 | 5.69 |
| CHEMBL144975 | — | — | 1 | 5.60 |
| CHEMBL144470 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146276 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL145082 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL145428 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL535811 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL9940 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL145573 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL144975 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL144470 | — | IC50 | = | 3150.0 | nM | 5.50 |