Assay Detail
Binding
CHEMBL618767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase in mouse macrophages.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL5211) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.64 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70191 | — | — | 1 | 8.30 |
| CHEMBL423835 | ZM-211965 | — | 1 | 8.10 |
| CHEMBL304320 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70191 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL423835 | ZM-211965 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL304320 | — | IC50 | = | 300.0 | nM | 6.52 |