Assay Detail
Binding
CHEMBL618921
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Affinity was evaluated as inhibition constant for serotonin 5-hydroxytryptamine 3 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.43 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.66 |
| CHEMBL73538 | — | — | 1 | 7.40 |
| CHEMBL266723 | — | — | 1 | 7.40 |
| CHEMBL7430 | — | — | 1 | 7.39 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.28 |
| CHEMBL269396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415300 | ISOCLOZAPINE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL73538 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL266723 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL7430 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL42 | CLOZAPINE | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL269396 | — | Ki | > | 1000.0 | nM | - |