Assay Detail
Functional
CHEMBL618927
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5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design of a potent 5-HT4 receptor agonist with nanomolar affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286136 | — | — | 1 | 8.40 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.30 |
| CHEMBL33732 | — | — | 1 | 7.66 |
| CHEMBL33676 | — | — | 1 | 7.57 |
| CHEMBL32986 | — | — | 1 | 7.36 |
| CHEMBL34224 | — | — | 1 | 6.96 |
| CHEMBL41769 | — | — | 1 | 6.96 |
| CHEMBL288199 | — | — | 1 | 6.82 |
| CHEMBL18041 | ZACOPRIDE | 2.0 | 1 | 6.58 |
| CHEMBL287045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286136 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL39 | SEROTONIN | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL33732 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL33676 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL32986 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL34224 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL41769 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL288199 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL18041 | ZACOPRIDE | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL287045 | — | EC50 | > | 1000.0 | nM | - |