Assay Detail
Functional
CHEMBL618929
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5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum
31
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 7.73 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158238 | — | — | 1 | 8.52 |
| CHEMBL286136 | — | — | 1 | 8.40 |
| CHEMBL157880 | — | — | 3 | 8.40 |
| CHEMBL348311 | — | — | 1 | 8.36 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.30 |
| CHEMBL156088 | — | — | 1 | 8.28 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL349809 | — | — | 1 | 8.22 |
| CHEMBL158147 | — | — | 1 | 8.11 |
| CHEMBL156348 | — | — | 1 | 7.89 |
| CHEMBL347235 | — | — | 1 | 7.85 |
| CHEMBL156349 | — | — | 1 | 7.82 |
| CHEMBL155631 | — | — | 1 | 7.77 |
| CHEMBL156554 | — | — | 1 | 7.72 |
| CHEMBL33676 | — | — | 1 | 7.57 |
| CHEMBL156579 | — | — | 1 | 7.54 |
| CHEMBL83954 | — | — | 1 | 7.52 |
| CHEMBL156970 | — | — | 1 | 7.40 |
| CHEMBL156965 | — | — | 1 | 7.40 |
| CHEMBL59834 | — | — | 1 | 7.37 |
| CHEMBL28992 | — | — | 1 | 7.11 |
| CHEMBL41769 | — | — | 1 | 6.96 |
| CHEMBL157631 | — | — | 1 | 6.95 |
| CHEMBL288199 | — | — | 1 | 6.82 |
| CHEMBL27846 | (R)ZACOPRIDE | — | 1 | 6.78 |
| CHEMBL160705 | — | — | 1 | 6.75 |
| CHEMBL351557 | — | — | 1 | - |
| CHEMBL420969 | — | — | 1 | - |
| CHEMBL156499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158238 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL286136 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL157880 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL348311 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL157880 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL39 | SEROTONIN | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL156088 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL86 | METOCLOPRAMIDE | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL349809 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL158147 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL157880 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL156348 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL347235 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL156349 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL155631 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL156554 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL33676 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL156579 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL83954 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL156970 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL156965 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL59834 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL28992 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL41769 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL157631 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL288199 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL27846 | (R)ZACOPRIDE | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL160705 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL351557 | — | EC50 | ~ | 930.0 | nM | - |
| CHEMBL420969 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL156499 | — | EC50 | > | 1000.0 | nM | - |