Assay Detail
Functional
CHEMBL619025
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Compound was evaluated for the agonistic activity towards 5-hydroxytryptamine 4 receptor using the rat tunica muscularis mucosae (TMM) esophagus strip assay
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Muscularis mucosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New aza(nor)adamantanes are agonists at the newly identified serotonin 5-HT4 receptor and antagonists at the 5-HT3 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.64 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2448165 | — | — | 1 | 7.29 |
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 7.26 |
| CHEMBL296522 | RENZAPRIDE | 3.0 | 1 | 7.01 |
| CHEMBL28992 | — | — | 1 | 6.69 |
| CHEMBL295155 | — | — | 2 | 6.58 |
| CHEMBL2448137 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2448165 | — | EC50 | = | 51.3 | nM | 7.29 |
| CHEMBL1729 | CISAPRIDE | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL296522 | RENZAPRIDE | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL28992 | — | EC50 | = | 203.0 | nM | 6.69 |
| CHEMBL295155 | — | EC50 | = | 262.0 | nM | 6.58 |
| CHEMBL295155 | — | EC50 | = | 538.0 | nM | 6.27 |
| CHEMBL2448137 | — | EC50 | = | 3870.0 | nM | 5.41 |