Assay Detail
Functional
CHEMBL619032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
5-hydroxytryptamine 4 receptor agonist activity was determined by the relaxation of the carbachol-contracted rat esophageal tunica muscularis mucosae
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design of a potent 5-HT4 receptor agonist with nanomolar affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.53 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286136 | — | — | 1 | 8.62 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286136 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL39 | SEROTONIN | IC50 | = | 3.7 | nM | 8.43 |