Assay Detail
Binding
CHEMBL619040
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Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand
41
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 7.99 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33884 | — | — | 1 | 9.82 |
| CHEMBL155917 | — | — | 2 | 9.59 |
| CHEMBL348311 | — | — | 1 | 9.04 |
| CHEMBL156349 | — | — | 1 | 9.03 |
| CHEMBL157880 | — | — | 3 | 9.00 |
| CHEMBL156348 | — | — | 1 | 8.98 |
| CHEMBL286136 | — | — | 1 | 8.97 |
| CHEMBL347235 | — | — | 1 | 8.85 |
| CHEMBL156554 | — | — | 1 | 8.85 |
| CHEMBL155682 | — | — | 1 | 8.76 |
| CHEMBL158238 | — | — | 1 | 8.39 |
| CHEMBL156970 | — | — | 1 | 8.27 |
| CHEMBL158147 | — | — | 1 | 8.26 |
| CHEMBL287045 | — | — | 1 | 8.26 |
| CHEMBL156088 | — | — | 1 | 8.22 |
| CHEMBL155631 | — | — | 1 | 8.21 |
| CHEMBL351570 | — | — | 1 | 8.20 |
| CHEMBL160237 | — | — | 1 | 8.12 |
| CHEMBL349809 | — | — | 1 | 8.11 |
| CHEMBL156579 | — | — | 1 | 8.04 |
| CHEMBL156965 | — | — | 1 | 8.03 |
| CHEMBL83954 | — | — | 1 | 7.55 |
| CHEMBL157631 | — | — | 1 | 7.45 |
| CHEMBL157233 | — | — | 1 | 7.40 |
| CHEMBL160705 | — | — | 1 | 7.33 |
| CHEMBL301039 | — | — | 1 | 7.31 |
| CHEMBL33676 | — | — | 1 | 7.19 |
| CHEMBL288199 | — | — | 1 | 7.04 |
| CHEMBL351557 | — | — | 1 | 6.99 |
| CHEMBL420969 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33884 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL155917 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL348311 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL156349 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL157880 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL156348 | — | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL286136 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL156554 | — | Ki | = | 1.43 | nM | 8.85 |
| CHEMBL347235 | — | Ki | = | 1.42 | nM | 8.85 |
| CHEMBL155682 | — | Ki | = | 1.72 | nM | 8.76 |
| CHEMBL157880 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL155917 | — | Ki | = | 2.32 | nM | 8.63 |
| CHEMBL158238 | — | Ki | = | 4.08 | nM | 8.39 |
| CHEMBL157880 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL156970 | — | Ki | = | 5.35 | nM | 8.27 |
| CHEMBL158147 | — | Ki | = | 5.45 | nM | 8.26 |
| CHEMBL287045 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL156088 | — | Ki | = | 6.03 | nM | 8.22 |
| CHEMBL155631 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL351570 | — | Ki | = | 6.28 | nM | 8.20 |
| CHEMBL160237 | — | Ki | = | 7.64 | nM | 8.12 |
| CHEMBL349809 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL156579 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL156965 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL83954 | — | Ki | = | 28.1 | nM | 7.55 |
| CHEMBL157631 | — | Ki | = | 35.6 | nM | 7.45 |
| CHEMBL157233 | — | Ki | = | 39.5 | nM | 7.40 |
| CHEMBL160705 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL301039 | — | Ki | = | 48.6 | nM | 7.31 |
| CHEMBL33676 | — | Ki | = | 64.3 | nM | 7.19 |
| CHEMBL288199 | — | Ki | = | 91.4 | nM | 7.04 |
| CHEMBL351557 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL420969 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL39 | SEROTONIN | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL59834 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL28992 | — | Ki | = | 383.0 | nM | 6.42 |
| CHEMBL41769 | — | Ki | = | 488.0 | nM | 6.31 |
| CHEMBL27846 | (R)ZACOPRIDE | Ki | = | 1510.0 | nM | 5.82 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | > | 1000.0 | nM | - |
| CHEMBL76737 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL156499 | — | Ki | > | 1000.0 | nM | - |