Assay Detail
Binding
CHEMBL619041
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Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of a potent 5-HT4 receptor agonist with nanomolar affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.30 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286136 | — | — | 1 | 8.97 |
| CHEMBL287045 | — | — | 1 | 8.28 |
| CHEMBL33732 | — | — | 1 | 7.99 |
| CHEMBL34224 | — | — | 1 | 7.64 |
| CHEMBL32986 | — | — | 1 | 7.46 |
| CHEMBL33676 | — | — | 1 | 7.19 |
| CHEMBL288199 | — | — | 1 | 7.04 |
| CHEMBL41769 | — | — | 1 | 6.31 |
| CHEMBL18041 | ZACOPRIDE | 2.0 | 1 | 6.12 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286136 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL287045 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL33732 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL34224 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL32986 | — | Ki | = | 34.5 | nM | 7.46 |
| CHEMBL33676 | — | Ki | = | 64.3 | nM | 7.19 |
| CHEMBL288199 | — | Ki | = | 91.4 | nM | 7.04 |
| CHEMBL41769 | — | Ki | = | 488.0 | nM | 6.31 |
| CHEMBL18041 | ZACOPRIDE | Ki | = | 753.0 | nM | 6.12 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 975.0 | nM | 6.01 |