Assay Detail
Binding
CHEMBL619042
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Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological activity of a macrocyclic benzamide
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.71 | 7.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116913 | — | — | 1 | 7.53 |
| CHEMBL301039 | — | — | 2 | 7.32 |
| CHEMBL325109 | CLEBOPRIDE | 2.0 | 1 | 6.98 |
| CHEMBL164169 | — | — | 1 | 6.63 |
| CHEMBL28992 | — | — | 1 | 6.42 |
| CHEMBL164425 | — | — | 1 | 6.08 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116913 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL301039 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL325109 | CLEBOPRIDE | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL164169 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL28992 | — | Ki | = | 383.0 | nM | 6.42 |
| CHEMBL164425 | — | Ki | = | 832.0 | nM | 6.08 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 974.0 | nM | 6.01 |
| CHEMBL301039 | — | Ki | > | 1000.0 | nM | - |