Assay Detail
Binding
CHEMBL619043
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Binding affinity to 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum membrane
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 8.01 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329487 | — | — | 1 | 9.96 |
| CHEMBL262950 | — | — | 1 | 9.54 |
| CHEMBL94880 | — | — | 1 | 9.49 |
| CHEMBL97955 | — | — | 1 | 9.27 |
| CHEMBL95178 | — | — | 1 | 9.19 |
| CHEMBL97594 | — | — | 1 | 8.66 |
| CHEMBL94784 | — | — | 1 | 8.64 |
| CHEMBL316856 | — | — | 1 | 8.54 |
| CHEMBL327192 | — | — | 1 | 7.94 |
| CHEMBL98734 | — | — | 1 | 7.86 |
| CHEMBL97591 | — | — | 1 | 7.65 |
| CHEMBL94756 | — | — | 1 | 7.61 |
| CHEMBL94099 | — | — | 1 | 7.58 |
| CHEMBL319663 | — | — | 1 | 7.56 |
| CHEMBL98397 | — | — | 1 | 7.35 |
| CHEMBL329545 | — | — | 1 | 7.32 |
| CHEMBL18769 | — | — | 1 | 7.27 |
| CHEMBL314299 | — | — | 1 | 7.16 |
| CHEMBL96667 | — | — | 1 | 6.94 |
| CHEMBL94415 | — | — | 1 | 6.54 |
| CHEMBL18473 | — | — | 1 | 6.14 |
| CHEMBL279823 | — | — | 1 | - |
| CHEMBL420638 | — | — | 1 | - |
| CHEMBL330605 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329487 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL262950 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL94880 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL97955 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL95178 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL97594 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL94784 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL316856 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL327192 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL98734 | — | Ki | = | 13.7 | nM | 7.86 |
| CHEMBL97591 | — | Ki | = | 22.4 | nM | 7.65 |
| CHEMBL94756 | — | Ki | = | 24.6 | nM | 7.61 |
| CHEMBL94099 | — | Ki | = | 26.1 | nM | 7.58 |
| CHEMBL319663 | — | Ki | = | 27.8 | nM | 7.56 |
| CHEMBL98397 | — | Ki | = | 44.6 | nM | 7.35 |
| CHEMBL329545 | — | Ki | = | 48.2 | nM | 7.32 |
| CHEMBL18769 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL314299 | — | Ki | = | 69.2 | nM | 7.16 |
| CHEMBL96667 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL94415 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL18473 | — | Ki | = | 719.0 | nM | 6.14 |
| CHEMBL279823 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL420638 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL330605 | — | Ki | > | 1000.0 | nM | - |