Assay Detail
Binding
CHEMBL619093
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Binding affinity for 5-hydroxytryptamine 4 receptor by displacement of [3H]GR-113808 from guinea pig brain striatum.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
(R)-3-(6-chloro-1-isopropylbenzimidazole-4-carboxamido)quinuclidine: A high affinity ligand for the (R)-zacopride binding site
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.58 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145725 | — | — | 1 | 7.62 |
| CHEMBL142852 | — | — | 1 | 6.80 |
| CHEMBL28992 | — | — | 1 | 6.36 |
| CHEMBL27846 | (R)ZACOPRIDE | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145725 | — | Ki | = | 23.99 | nM | 7.62 |
| CHEMBL142852 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL28992 | — | Ki | = | 436.52 | nM | 6.36 |
| CHEMBL27846 | (R)ZACOPRIDE | Ki | = | 2818.38 | nM | 5.55 |