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Assay Detail

CHEMBL619178

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Affinity for 5-hydroxytryptamine receptor was determined using male Dawley rat fundus preparation
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Serotonin (5-HT) receptor (CHEMBL2094123)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Serotonin receptor affinity of cathinone and related analogues.
Glennon RA, Liebowitz SM.
J Med Chem (1982) 25 : 393 -397
PubMed 7069716 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 15 5.56 6.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL129038 1 6.14
CHEMBL338085 1 6.12
CHEMBL128393 1 6.04
CHEMBL128075 1 5.94
CHEMBL1124 DEALKYLATED DIETHYLPROPION 2 5.86
CHEMBL341279 1 5.81
CHEMBL99959 1 5.65
CHEMBL30294 1 5.61
CHEMBL1204 HYDROXYLATED COMPLETELY DELAKYLATED DIETHYLPROPION 1 5.30
CHEMBL405 AMPHETAMINE 4.0 1 5.27
CHEMBL610 PHENETHYLAMINE 1 5.26
CHEMBL318060 1 4.95
CHEMBL337382 1 4.94
CHEMBL128078 1 4.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL129038 Kd = 724.44 nM 6.14
CHEMBL338085 Kd = 758.58 nM 6.12
CHEMBL128393 Kd = 912.01 nM 6.04
CHEMBL128075 Kd = 1148.15 nM 5.94
CHEMBL1124 DEALKYLATED DIETHYLPROPION Kd = 1380.38 nM 5.86
CHEMBL341279 Kd = 1548.82 nM 5.81
CHEMBL99959 Kd = 2238.72 nM 5.65
CHEMBL30294 Kd = 2454.71 nM 5.61
CHEMBL1124 DEALKYLATED DIETHYLPROPION Kd = 2818.38 nM 5.55
CHEMBL1204 HYDROXYLATED COMPLETELY DELAKYLATED DIETHYLPROPION Kd = 5011.87 nM 5.30
CHEMBL405 AMPHETAMINE Kd = 5370.32 nM 5.27
CHEMBL610 PHENETHYLAMINE Kd = 5495.41 nM 5.26
CHEMBL318060 Kd = 11220.18 nM 4.95
CHEMBL337382 Kd = 11481.54 nM 4.94
CHEMBL128078 Kd = 12589.25 nM 4.90