Assay Detail
Binding
CHEMBL619189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.16 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 8.30 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 7.36 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 7.36 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 1 | 6.77 |
| CHEMBL1628227 | DOXEPIN | 4.0 | 1 | 6.70 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 6.46 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL11 | IMIPRAMINE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1628227 | DOXEPIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL72 | DESIPRAMINE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL6437 | MIANSERIN | IC50 | > | 5000.0 | nM | - |