Assay Detail
Binding
CHEMBL619203
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity constant on CHO cells expressing Human recombinant 5-hydroxytryptamine receptor 1A
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.47 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43116 | — | — | 1 | 10.17 |
| CHEMBL13647 | BMY-7378 | — | 1 | 9.43 |
| CHEMBL42231 | — | — | 1 | 8.20 |
| CHEMBL42472 | — | — | 1 | 8.19 |
| CHEMBL40325 | — | — | 1 | 7.99 |
| CHEMBL42558 | — | — | 1 | 7.97 |
| CHEMBL44403 | — | — | 1 | 7.96 |
| CHEMBL43905 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43116 | — | Ki | = | 0.06761 | nM | 10.17 |
| CHEMBL13647 | BMY-7378 | Ki | = | 0.3715 | nM | 9.43 |
| CHEMBL42231 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL42472 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL40325 | — | Ki | = | 10.23 | nM | 7.99 |
| CHEMBL42558 | — | Ki | = | 10.72 | nM | 7.97 |
| CHEMBL44403 | — | Ki | = | 10.96 | nM | 7.96 |
| CHEMBL43905 | — | Ki | = | 15.14 | nM | 7.82 |