Assay Detail
Binding
CHEMBL619227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 5-lipoxygenase (5-LO) using broken rat barophilic leukemia cells (RBL-1)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.84 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL369848 | — | — | 1 | 8.00 |
| CHEMBL175150 | — | — | 1 | 7.16 |
| CHEMBL177727 | — | — | 1 | 7.16 |
| CHEMBL175153 | — | — | 1 | 7.10 |
| CHEMBL368682 | — | — | 1 | 7.00 |
| CHEMBL366595 | — | — | 1 | 6.62 |
| CHEMBL367010 | — | — | 1 | 6.57 |
| CHEMBL174684 | — | — | 1 | 6.55 |
| CHEMBL173939 | — | — | 1 | 6.43 |
| CHEMBL264200 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL369848 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL175150 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL177727 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL175153 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL368682 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL366595 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL367010 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL174684 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL173939 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL264200 | — | IC50 | = | 1660.0 | nM | 5.78 |