Assay Detail
Binding
CHEMBL619230
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Inhibitory activity against 5-lipoxygenase of RBL-1 cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.93 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85000 | — | — | 1 | 7.72 |
| CHEMBL36648 | LONAPALENE | 2.0 | 1 | 6.13 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL108795 | — | — | 1 | - |
| CHEMBL321024 | — | — | 1 | - |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85000 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL36648 | LONAPALENE | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 25000.0 | nM | - |
| CHEMBL108795 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL321024 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL157101 | KETOCONAZOLE | IC50 | > | 25000.0 | nM | - |