Assay Detail
Binding
CHEMBL619232
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Inhibitory activity against intact rat PMNL, LTB4 5-lipoxygenase was evaluated
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.71 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7660 | PHENIDONE | — | 1 | 6.28 |
| CHEMBL30110 | — | — | 1 | 5.92 |
| CHEMBL274642 | BW-755C | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7660 | PHENIDONE | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL30110 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL274642 | BW-755C | IC50 | = | 12000.0 | nM | 4.92 |