Assay Detail
Binding
CHEMBL619237
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Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.85 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129761 | — | — | 1 | 5.52 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.50 |
| CHEMBL313417 | — | — | 1 | 5.00 |
| CHEMBL126023 | — | — | 1 | 4.22 |
| CHEMBL96741 | — | — | 1 | 4.00 |
| CHEMBL128638 | — | — | 1 | - |
| CHEMBL63135 | — | — | 1 | - |
| CHEMBL14112 | SB-210313 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129761 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL93 | ZILEUTON | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL313417 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL126023 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL96741 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL128638 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63135 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL14112 | SB-210313 | IC50 | > | 100000.0 | nM | - |