Assay Detail
Binding
CHEMBL619239
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In vitro inhibition of rat polymorphonuclear leukocyte 5-lipoxygenase
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.62 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301253 | — | — | 1 | 7.30 |
| CHEMBL52085 | — | — | 1 | 7.10 |
| CHEMBL54453 | — | — | 1 | 7.00 |
| CHEMBL52749 | — | — | 1 | 7.00 |
| CHEMBL55133 | — | — | 1 | 7.00 |
| CHEMBL54013 | — | — | 1 | 7.00 |
| CHEMBL55620 | — | — | 1 | 7.00 |
| CHEMBL54360 | — | — | 1 | 6.96 |
| CHEMBL293264 | — | — | 1 | 6.92 |
| CHEMBL53028 | — | — | 1 | 6.82 |
| CHEMBL54838 | — | — | 1 | 6.60 |
| CHEMBL55762 | — | — | 1 | 6.52 |
| CHEMBL444315 | — | — | 1 | 6.52 |
| CHEMBL55053 | — | — | 1 | 6.52 |
| CHEMBL415963 | — | — | 1 | 6.52 |
| CHEMBL54438 | — | — | 1 | 6.52 |
| CHEMBL52748 | — | — | 1 | 6.50 |
| CHEMBL52896 | — | — | 1 | 6.46 |
| CHEMBL52241 | — | — | 1 | 6.30 |
| CHEMBL53393 | — | — | 1 | 6.00 |
| CHEMBL52572 | — | — | 1 | 6.00 |
| CHEMBL51687 | — | — | 1 | 6.00 |
| CHEMBL55172 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301253 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL52085 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL54453 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL52749 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL55133 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL54013 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL55620 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL54360 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL293264 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL53028 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL54838 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL55762 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL444315 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL55053 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL415963 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL54438 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL52748 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL52896 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL52241 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL53393 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL52572 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL51687 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL55172 | — | IC50 | = | 2500.0 | nM | 5.60 |