Assay Detail
Binding
CHEMBL619241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of 5-Lipoxygenase (ARBL) in calcium-stimulated rat basophilic leukemia cells(RBL-1)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of reversed hydroxamic acids of indomethacin: dual inhibitors of cyclooxygenase and 5-lipoxygenase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.00 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42593 | — | — | 1 | 6.47 |
| CHEMBL295243 | — | — | 1 | 6.40 |
| CHEMBL295008 | — | — | 1 | 6.24 |
| CHEMBL296543 | — | — | 1 | 6.08 |
| CHEMBL410500 | — | — | 1 | 5.85 |
| CHEMBL46871 | — | — | 1 | 5.85 |
| CHEMBL295829 | OXAMETACIN | 2.0 | 1 | 5.12 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42593 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL295243 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL295008 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL296543 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL410500 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL46871 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL295829 | OXAMETACIN | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 100000.0 | nM | - |