Assay Detail
Binding
CHEMBL619255
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Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytes
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin--antiproliferative activity and 5-lipoxygenase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.40 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36648 | LONAPALENE | 2.0 | 1 | 6.30 |
| CHEMBL46487 | — | — | 1 | 6.22 |
| CHEMBL44921 | — | — | 1 | 6.05 |
| CHEMBL433067 | — | — | 1 | 6.00 |
| CHEMBL44811 | — | — | 1 | 5.70 |
| CHEMBL47046 | — | — | 1 | 5.70 |
| CHEMBL45410 | — | — | 1 | 5.70 |
| CHEMBL417717 | — | — | 1 | 5.40 |
| CHEMBL291181 | — | — | 1 | 5.40 |
| CHEMBL44880 | — | — | 1 | 5.30 |
| CHEMBL432858 | — | — | 1 | 5.30 |
| CHEMBL45142 | — | — | 1 | 5.22 |
| CHEMBL46432 | — | — | 1 | 5.16 |
| CHEMBL46543 | — | — | 1 | 5.16 |
| CHEMBL289482 | — | — | 1 | 4.96 |
| CHEMBL47042 | — | — | 1 | 4.75 |
| CHEMBL288995 | — | — | 1 | 4.52 |
| CHEMBL46469 | ANTHRALIN | 2.0 | 1 | 4.43 |
| CHEMBL46826 | — | — | 1 | - |
| CHEMBL47024 | — | — | 1 | - |
| CHEMBL295624 | — | — | 1 | - |
| CHEMBL288568 | — | — | 1 | - |
| CHEMBL44375 | — | — | 1 | - |
| CHEMBL44061 | — | — | 1 | - |
| CHEMBL44943 | — | — | 1 | - |
| CHEMBL43732 | — | — | 1 | - |
| CHEMBL296298 | — | — | 1 | - |
| CHEMBL297109 | — | — | 1 | - |
| CHEMBL46448 | — | — | 1 | - |
| CHEMBL296462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36648 | LONAPALENE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL46487 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL44921 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL433067 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL44811 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL47046 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL45410 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL417717 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL291181 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL44880 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL432858 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL45142 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL46432 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL46543 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL289482 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL47042 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL288995 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL46469 | ANTHRALIN | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL42406 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL46886 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL42460 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL296136 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL44843 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL295553 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL298103 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL44994 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL45329 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL45104 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL296462 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL46448 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL297109 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL296298 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL43732 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL44943 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL44061 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL44375 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL288568 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL295624 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL47024 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL46826 | — | IC50 | > | 30000.0 | nM | - |