Assay Detail
Binding
CHEMBL619256
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Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.57 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335405 | — | — | 1 | 6.52 |
| CHEMBL133113 | — | — | 1 | 6.52 |
| CHEMBL133805 | — | — | 1 | 6.40 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.40 |
| CHEMBL107703 | — | — | 1 | 6.30 |
| CHEMBL36648 | LONAPALENE | 2.0 | 1 | 6.30 |
| CHEMBL130560 | — | — | 1 | 6.30 |
| CHEMBL130302 | — | — | 1 | 6.30 |
| CHEMBL130038 | — | — | 1 | 6.22 |
| CHEMBL134029 | — | — | 1 | 6.00 |
| CHEMBL132621 | — | — | 1 | 6.00 |
| CHEMBL337845 | — | — | 1 | 5.70 |
| CHEMBL132745 | — | — | 1 | 5.70 |
| CHEMBL334954 | — | — | 1 | 5.70 |
| CHEMBL433846 | — | — | 1 | 5.52 |
| CHEMBL131667 | — | — | 1 | 5.40 |
| CHEMBL130581 | — | — | 1 | 5.22 |
| CHEMBL130382 | — | — | 1 | 5.22 |
| CHEMBL134069 | — | — | 1 | 5.16 |
| CHEMBL130209 | — | — | 1 | 5.00 |
| CHEMBL334941 | — | — | 1 | 4.96 |
| CHEMBL132990 | — | — | 1 | 4.96 |
| CHEMBL130360 | — | — | 1 | 4.85 |
| CHEMBL133058 | — | — | 1 | 4.85 |
| CHEMBL130792 | — | — | 1 | 4.77 |
| CHEMBL336428 | — | — | 1 | 4.77 |
| CHEMBL130968 | BUTANTRONE | 2.0 | 1 | 4.48 |
| CHEMBL46469 | ANTHRALIN | 2.0 | 1 | 4.43 |
| CHEMBL337831 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335405 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL133113 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL133805 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL107703 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL36648 | LONAPALENE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL130560 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL130302 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL130038 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL134029 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL132621 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL337845 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL132745 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL334954 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL433846 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL131667 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL130581 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL130382 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL134069 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL130209 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL334941 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL132990 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL130360 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL133058 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL130792 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL336428 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL130968 | BUTANTRONE | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL46469 | ANTHRALIN | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL337831 | — | IC50 | = | - | nM | - |