Assay Detail
Binding
CHEMBL619259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | PMNL |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.72 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57062 | — | — | 1 | 6.75 |
| CHEMBL300982 | LICOFELONE | 2.0 | 1 | 6.75 |
| CHEMBL56161 | — | — | 1 | 6.62 |
| CHEMBL292239 | — | — | 1 | 5.82 |
| CHEMBL294159 | — | — | 1 | 5.80 |
| CHEMBL55414 | — | — | 1 | 5.80 |
| CHEMBL54485 | — | — | 1 | 5.77 |
| CHEMBL301693 | — | — | 1 | 5.77 |
| CHEMBL54486 | — | — | 1 | 5.75 |
| CHEMBL56034 | — | — | 1 | 5.68 |
| CHEMBL54506 | — | — | 1 | 5.40 |
| CHEMBL56033 | — | — | 1 | 5.37 |
| CHEMBL56294 | — | — | 1 | 5.36 |
| CHEMBL56600 | — | — | 1 | 5.28 |
| CHEMBL291487 | — | — | 1 | 5.22 |
| CHEMBL54658 | — | — | 1 | 5.11 |
| CHEMBL300670 | — | — | 1 | 5.00 |
| CHEMBL301264 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57062 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL300982 | LICOFELONE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL56161 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL292239 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL294159 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL55414 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL54485 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL301693 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL54486 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL56034 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL54506 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL56033 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL56294 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL56600 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL291487 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL54658 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL300670 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL301264 | — | IC50 | > | 10000.0 | nM | - |