Assay Detail
Binding
CHEMBL619381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against murine lipoxygenase-2.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL5211) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.25 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304818 | DOCEBENONE | 2.0 | 1 | 7.50 |
| CHEMBL85649 | — | — | 1 | 6.43 |
| CHEMBL88104 | — | — | 1 | 5.32 |
| CHEMBL314588 | — | — | 1 | 5.23 |
| CHEMBL86023 | — | — | 1 | 5.19 |
| CHEMBL86153 | — | — | 1 | 5.12 |
| CHEMBL87417 | — | — | 1 | 5.12 |
| CHEMBL284742 | — | — | 1 | 5.09 |
| CHEMBL315053 | — | — | 1 | 5.02 |
| CHEMBL315587 | — | — | 1 | 5.00 |
| CHEMBL314559 | — | — | 1 | 4.92 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.91 |
| CHEMBL315017 | — | — | 1 | 4.89 |
| CHEMBL315421 | — | — | 1 | 4.87 |
| CHEMBL315813 | — | — | 1 | 4.87 |
| CHEMBL84837 | — | — | 1 | 4.86 |
| CHEMBL87561 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304818 | DOCEBENONE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL85649 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL88104 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL314588 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL86023 | — | IC50 | = | 6510.0 | nM | 5.19 |
| CHEMBL86153 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL87417 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL284742 | — | IC50 | = | 8130.0 | nM | 5.09 |
| CHEMBL315053 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL315587 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL314559 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL7976 | CHALCONE | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL315017 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL315421 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL315813 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL84837 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL87561 | — | IC50 | = | 14000.0 | nM | 4.85 |