Assay Detail
Binding
CHEMBL619397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.99 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8747 | REV-5901 | — | 1 | 6.92 |
| CHEMBL8384 | — | — | 1 | 6.89 |
| CHEMBL8549 | — | — | 1 | 6.43 |
| CHEMBL8440 | — | — | 1 | 6.37 |
| CHEMBL594621 | ICOMUCRET | 2.0 | 1 | 5.84 |
| CHEMBL8841 | — | — | 1 | 5.72 |
| CHEMBL274852 | — | — | 1 | 5.70 |
| CHEMBL8257 | — | — | 1 | 5.40 |
| CHEMBL8622 | — | — | 1 | 5.40 |
| CHEMBL8797 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8747 | REV-5901 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL8384 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL8549 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL8440 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL594621 | ICOMUCRET | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL8841 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL274852 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL8257 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL8622 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL8797 | — | IC50 | = | 6000.0 | nM | 5.22 |