Assay Detail
Binding
CHEMBL619410
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenase
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 4.50 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1606580 | — | — | 1 | 5.47 |
| CHEMBL7660 | PHENIDONE | — | 1 | 5.23 |
| CHEMBL3349312 | — | — | 1 | 5.19 |
| CHEMBL3349315 | — | — | 1 | 5.14 |
| CHEMBL594621 | ICOMUCRET | 2.0 | 1 | 5.14 |
| CHEMBL3349314 | — | — | 1 | 4.77 |
| CHEMBL276929 | — | — | 1 | 4.64 |
| CHEMBL313548 | — | — | 1 | 4.60 |
| CHEMBL418941 | — | — | 1 | 4.58 |
| CHEMBL3349320 | — | — | 1 | 4.58 |
| CHEMBL329014 | — | — | 1 | 4.57 |
| CHEMBL3085211 | — | — | 1 | 4.54 |
| CHEMBL327452 | — | — | 1 | 4.50 |
| CHEMBL420428 | — | — | 1 | 4.46 |
| CHEMBL88863 | — | — | 1 | 4.26 |
| CHEMBL439584 | — | — | 1 | 4.24 |
| CHEMBL89686 | — | — | 1 | 4.21 |
| CHEMBL3349316 | — | — | 1 | 4.21 |
| CHEMBL3349313 | — | — | 1 | 4.19 |
| CHEMBL86330 | — | — | 1 | 4.18 |
| CHEMBL86789 | — | — | 1 | 4.14 |
| CHEMBL420056 | — | — | 1 | 4.12 |
| CHEMBL17695 | — | — | 1 | 4.11 |
| CHEMBL3349318 | — | — | 1 | 4.11 |
| CHEMBL88774 | — | — | 1 | 4.09 |
| CHEMBL451721 | — | — | 1 | 4.09 |
| CHEMBL3349317 | — | — | 1 | 4.03 |
| CHEMBL89644 | — | — | 1 | - |
| CHEMBL86855 | — | — | 1 | - |
| CHEMBL442379 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1606580 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3349312 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3349315 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL594621 | ICOMUCRET | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3349314 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL276929 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL313548 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL418941 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3349320 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL329014 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3085211 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL327452 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL420428 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL88863 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL439584 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL89686 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL3349316 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL3349313 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL86330 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL86789 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL420056 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL17695 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL3349318 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL88774 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL451721 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL3349317 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL89644 | — | IC50 | = | 270000.0 | nM | - |
| CHEMBL86855 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL442379 | — | IC50 | = | 260000.0 | nM | - |