Assay Detail
Binding
CHEMBL619416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]quipazine as radioligand in rat cortex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.23 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 9.22 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 9.00 |
| CHEMBL289469 | GRANISETRON | 4.0 | 1 | 8.04 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56564 | TROPISETRON | Ki | = | 0.6026 | nM | 9.22 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL289469 | GRANISETRON | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 229.09 | nM | 6.64 |