Assay Detail
Functional
CHEMBL619756
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5-hydroxytryptamine 4 receptor antagonist activity expressed as the concentration which produced a 50% reduction of 5-HT induced contraction in guinea pig ileum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design of a potent 5-HT4 receptor agonist with nanomolar affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.03 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41769 | — | — | 1 | 7.52 |
| CHEMBL34224 | — | — | 1 | 7.22 |
| CHEMBL288199 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41769 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL34224 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL288199 | — | IC50 | = | 450.0 | nM | 6.35 |