Assay Detail
Functional
CHEMBL619759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
5-hydroxytryptamine 4 receptor antagonist activity, concentration which gave 50% reduction of the 5-HT-induced contractions in the guinea pig ileum
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.08 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155917 | — | — | 2 | 7.96 |
| CHEMBL33884 | — | — | 1 | 7.89 |
| CHEMBL41769 | — | — | 1 | 7.52 |
| CHEMBL287045 | — | — | 1 | 7.11 |
| CHEMBL123377 | — | — | 1 | 7.00 |
| CHEMBL160237 | — | — | 1 | 7.00 |
| CHEMBL155682 | — | — | 1 | 6.82 |
| CHEMBL156970 | — | — | 1 | 6.70 |
| CHEMBL351570 | — | — | 1 | 6.52 |
| CHEMBL288199 | — | — | 1 | 6.35 |
| CHEMBL160705 | — | — | 1 | 6.22 |
| CHEMBL156499 | — | — | 1 | - |
| CHEMBL420969 | — | — | 1 | - |
| CHEMBL156088 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155917 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL155917 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL33884 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL41769 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL287045 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL123377 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL160237 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL155682 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL156970 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL351570 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL288199 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL160705 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL156499 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL420969 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL156088 | — | IC50 | ~ | 20.0 | nM | - |