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Assay Detail

CHEMBL619781

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ability to displace [3H]quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Serotonin 3 (5-HT3) receptor (CHEMBL2094116)
Type PROTEIN COMPLEX
Organism Rattus norvegicus

Publication

5-HT3 receptor antagonists. 1. New quinoline derivatives.
Hayashi H, Miwa Y, Miki I, Ichikawa S, Yoda N, Ishii A, Kono M, Suzuki F.
J Med Chem (1992) 35 : 4893 -4902
PubMed 1479589 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 32 8.60 10.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL111448 1 10.49
CHEMBL148076 1 9.51
CHEMBL148430 1 9.49
CHEMBL111059 1 9.41
CHEMBL113742 1 9.36
CHEMBL325349 1 9.35
CHEMBL113519 1 9.33
CHEMBL333371 1 9.29
CHEMBL112941 1 9.24
CHEMBL112237 1 9.17
CHEMBL321477 1 9.07
CHEMBL325235 1 9.06
CHEMBL113204 1 9.02
CHEMBL322751 1 8.96
CHEMBL112224 1 8.96
CHEMBL114444 1 8.89
CHEMBL326545 1 8.82
CHEMBL419012 1 8.59
CHEMBL423687 1 8.49
CHEMBL424117 1 8.06
CHEMBL114080 1 7.72
CHEMBL109813 1 7.38
CHEMBL144560 1 7.36
CHEMBL332037 1 7.28
CHEMBL324243 1 7.22
CHEMBL112942 1 7.20
CHEMBL113118 1 7.17
CHEMBL359246 1 6.80
CHEMBL343836 1 -
CHEMBL148209 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL111448 Ki = 0.032 nM 10.49
CHEMBL148076 Ki = 0.31 nM 9.51
CHEMBL148430 Ki = 0.32 nM 9.49
CHEMBL111059 Ki = 0.39 nM 9.41
CHEMBL113742 Ki = 0.44 nM 9.36
CHEMBL325349 Ki = 0.45 nM 9.35
CHEMBL113519 Ki = 0.47 nM 9.33
CHEMBL333371 Ki = 0.51 nM 9.29
CHEMBL112941 Ki = 0.58 nM 9.24
CHEMBL112237 Ki = 0.68 nM 9.17
CHEMBL321477 Ki = 0.86 nM 9.07
CHEMBL325235 Ki = 0.88 nM 9.06
CHEMBL113204 Ki = 0.96 nM 9.02
CHEMBL322751 Ki = 1.1 nM 8.96
CHEMBL112224 Ki = 1.1 nM 8.96
CHEMBL114444 Ki = 1.3 nM 8.89
CHEMBL326545 Ki = 1.5 nM 8.82
CHEMBL419012 Ki = 2.6 nM 8.59
CHEMBL423687 Ki = 3.2 nM 8.49
CHEMBL424117 Ki = 8.7 nM 8.06
CHEMBL114080 Ki = 19.0 nM 7.72
CHEMBL109813 Ki = 42.0 nM 7.38
CHEMBL144560 Ki = 44.0 nM 7.36
CHEMBL332037 Ki = 53.0 nM 7.28
CHEMBL324243 Ki = 60.0 nM 7.22
CHEMBL112942 Ki = 63.0 nM 7.20
CHEMBL113118 Ki = 67.0 nM 7.17
CHEMBL359246 Ki = 160.0 nM 6.80
CHEMBL343836 Ki > 100.0 nM -
CHEMBL148209 Ki > 100.0 nM -
CHEMBL434652 Ki > 100.0 nM -
CHEMBL342574 Ki > 100.0 nM -