Assay Detail
Binding
CHEMBL619783
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Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.13 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289469 | GRANISETRON | 4.0 | 1 | 9.22 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 8.85 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.49 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 8.48 |
| CHEMBL2107804 | BEMESETRON | 2.0 | 1 | 7.27 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289469 | GRANISETRON | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL56564 | TROPISETRON | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL46 | ONDANSETRON | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL2107804 | BEMESETRON | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 348.0 | nM | 6.46 |