Assay Detail
Binding
CHEMBL619792
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Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]BRL-43694 displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Entorhinal cortex |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Derivatives of quinuclidine as 5-HT3 receptor antagonists: influence of an additional carbonyl group on the recognition of chirality by the receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.72 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289126 | — | — | 1 | 9.82 |
| CHEMBL28992 | — | — | 1 | 9.70 |
| CHEMBL288199 | — | — | 1 | 9.15 |
| CHEMBL27846 | (R)ZACOPRIDE | — | 1 | 8.59 |
| CHEMBL41769 | — | — | 1 | 8.44 |
| CHEMBL38418 | — | — | 1 | 8.22 |
| CHEMBL289148 | — | — | 1 | 7.95 |
| CHEMBL290866 | — | — | 1 | 7.72 |
| CHEMBL43127 | — | — | 1 | 7.63 |
| CHEMBL290730 | — | — | 1 | 7.50 |
| CHEMBL39455 | — | — | 1 | 7.14 |
| CHEMBL432483 | — | — | 1 | 7.00 |
| CHEMBL416805 | — | — | 1 | 6.92 |
| CHEMBL43243 | — | — | 1 | 6.83 |
| CHEMBL38993 | — | — | 1 | 6.47 |
| CHEMBL290132 | — | — | 1 | 6.39 |
| CHEMBL41294 | — | — | 1 | 5.72 |
| CHEMBL433452 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289126 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL28992 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL288199 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL27846 | (R)ZACOPRIDE | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL41769 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL38418 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL289148 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL290866 | — | Ki | = | 18.9 | nM | 7.72 |
| CHEMBL43127 | — | Ki | = | 23.4 | nM | 7.63 |
| CHEMBL290730 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL39455 | — | Ki | = | 71.6 | nM | 7.14 |
| CHEMBL432483 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL416805 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL43243 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL38993 | — | Ki | = | 342.0 | nM | 6.47 |
| CHEMBL290132 | — | Ki | = | 409.0 | nM | 6.39 |
| CHEMBL41294 | — | Ki | = | 1890.0 | nM | 5.72 |
| CHEMBL433452 | — | Ki | > | 1e-06 | nM | - |