Assay Detail
Binding
CHEMBL619796
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Binding affinity at 5-hydroxytryptamine 3 receptor in rat posterior cortex by [3H]-BRL 43694 displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Derivatives of naphthalimide: new potent conformationally restricted antagonists of 5-HT3 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.14 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350824 | — | — | 1 | 9.82 |
| CHEMBL28992 | — | — | 1 | 9.70 |
| CHEMBL161069 | — | — | 1 | 9.30 |
| CHEMBL161922 | — | — | 1 | 9.05 |
| CHEMBL351218 | — | — | 1 | 8.66 |
| CHEMBL162123 | — | — | 1 | 8.64 |
| CHEMBL27846 | (R)ZACOPRIDE | — | 1 | 8.59 |
| CHEMBL348156 | — | — | 1 | 8.57 |
| CHEMBL159552 | — | — | 1 | 7.85 |
| CHEMBL159609 | — | — | 1 | 7.82 |
| CHEMBL159305 | — | — | 1 | 7.66 |
| CHEMBL350489 | — | — | 1 | 7.63 |
| CHEMBL160087 | — | — | 1 | 7.52 |
| CHEMBL346555 | — | — | 1 | 7.51 |
| CHEMBL350423 | — | — | 1 | 7.39 |
| CHEMBL349472 | — | — | 1 | 7.21 |
| CHEMBL351217 | — | — | 1 | 7.10 |
| CHEMBL161113 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350824 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL28992 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL161069 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL161922 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL351218 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL162123 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL27846 | (R)ZACOPRIDE | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL348156 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL159552 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL159609 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL159305 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL350489 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL160087 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL346555 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL350423 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL349472 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL351217 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL161113 | — | Ki | = | 374.0 | nM | 6.43 |