Assay Detail
Binding
CHEMBL619895
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Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
First pharmacophoric hypothesis for 5-HT7 antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.74 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274595 | — | — | 1 | 7.80 |
| CHEMBL12771 | — | — | 1 | 7.70 |
| CHEMBL12777 | — | — | 1 | 7.50 |
| CHEMBL12264 | SB-258719 | — | 1 | 7.50 |
| CHEMBL275996 | — | — | 1 | 7.50 |
| CHEMBL13049 | — | — | 1 | 7.20 |
| CHEMBL12389 | — | — | 1 | 6.90 |
| CHEMBL12654 | — | — | 1 | 6.20 |
| CHEMBL267543 | — | — | 1 | 5.80 |
| CHEMBL273890 | — | — | 1 | 5.00 |
| CHEMBL276255 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274595 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL12771 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL12777 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL12264 | SB-258719 | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL275996 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL13049 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL12389 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL12654 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL267543 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL273890 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL276255 | — | Ki | = | 10000.0 | nM | 5.00 |