Compound Detail
CHEMBL275996
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Basic Information
| ChEMBL ID | CHEMBL275996 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZVZBMRUPOUQIJT-CQSZACIVSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
393.4
MW (Da)
4.12
ALogP
3
HBA
0
HBD
40.6
PSA (Ų)
0.73
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 7.5 | 7.5 | 31.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 31.62 | nM | 7.5 | Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed i... | 9513592 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 31.62 | nM | 7.5 | Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 ... | 10843226 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9513592 | 10.1021/jm970519e | 5-hydroxytryptamine receptor 7 | 1 |
| 10843226 | 10.1016/s0960-894x(00)00166-9 | 5-hydroxytryptamine receptor 7 | 1 |
Data from ChEMBL 36 via Core Engine