Assay Detail
Binding
CHEMBL619903
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Evaluated in vitro for its inhibitory activity against 5-lipoxygenase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.68 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543891 | — | — | 1 | 6.85 |
| CHEMBL17091 | — | — | 1 | 6.48 |
| CHEMBL542464 | — | — | 1 | 6.43 |
| CHEMBL543650 | — | — | 1 | 5.92 |
| CHEMBL331793 | — | — | 1 | 5.77 |
| CHEMBL331069 | — | — | 1 | 5.64 |
| CHEMBL331523 | — | — | 1 | 5.60 |
| CHEMBL44957 | — | — | 1 | 5.60 |
| CHEMBL545288 | — | — | 1 | 5.58 |
| CHEMBL333579 | — | — | 1 | 5.48 |
| CHEMBL331489 | — | — | 1 | 5.47 |
| CHEMBL123459 | — | — | 1 | 5.44 |
| CHEMBL553736 | — | — | 1 | 5.17 |
| CHEMBL542941 | — | — | 1 | 5.11 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | 4.0 | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543891 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL17091 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL542464 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL543650 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL331793 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL331069 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL331523 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL44957 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL545288 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL333579 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL331489 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL123459 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL553736 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL542941 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | IC50 | = | 24000.0 | nM | 4.62 |